Kuedza kwakaratidza kuwanda kweiyo quaternary ammonium disinfectants sekurapa mavhairasi mazhinji, kusanganisira coronaviruses: aya anoita nekudzima inodzivirira lipid coating iyo yakaputira hutachiona seSARS-CoV-2 inovimba nayo.Quaternary ammonium compounds inokurudzirwa zvakanyanya kuuraya mavhairasi uye kune zvinopfuura mazana matatu nemakumi mashanu zvigadzirwa paEPA's Rondedzero N: Disinfectants zvekushandisa kurwisa SARS-CoV-2 (Supplementary Material. Iyo disinfectant concentrations uye nguva yekubata (inobatanidzwa neakawanda mavhairasi) kune akawanda ekuuraya utachiona. makemikari ari pachirongwa cheEPA akataurwa uye> 140 inogona kudzima hutachiona mumaminitsi mashoma (18).
Ruzivo urwu rwakatitungamira mukutsvagisa kwakakura kwequaternary ammonium compounds ine chiitiko kurwisa coronavirus uye zvinokwanisika kuzivikanwa kwemakemikari akatoongororwa mukiriniki uye anogona kushandiswa seangangoita kurapa COVID-19.Imwe yemishonga inouraya utachiona yakaratidzwa kuva inoparadza mavhairasi (Supplementary Material) uye inoshandiswa zvakanyanya muzvigadzirwa zvekuchengeta munhu ndeye cetylpyridinium chloride.Mushonga uyu unowanikwa zvakanyanya mukugezeswa mukanwa uye wakanyorwa neFDA seInotariswa Kazhinji SeYakachengeteka (GRAS) zvekuti uri kushandiswawo seantimicrobial agent yezvigadzirwa zvenyama nehuku (kusvika 1%).Cetylpyridinium chloride yakashandiswa mumakiriniki akawanda miedzo, kusanganisira semushonga unopokana nehutachiona hwekufema uchisimbisa kushandiswa kwayo seantiviral.Cetylpyridinium inogona kukurudzira kusashanda kwehutachiona nekuparadza iyo capsid pamwe nekuita kwayo lysosomotropic, iyo, sezvakakurukurwa pamusoro apa, inowanzoitika kune quaternary ammonium compounds.Izvi zvinomutsa mubvunzo wekuti mimwe yemishonga inotaridzwa neantiviral chiitiko ichipokana neSARS-CoV-2 in vitro inoita zvakafanana here, zvekuti inogona kuparadza hutachiona capsid pamwe nekuunganidza mu lysosome kana endosomes uye pakupedzisira ichivharira hutachiona kupinda.Zvimwe zvidzidzo zvakadhindwa zvakaratidza kuti chiitiko ichi chinogona kudzikiswa nekushandiswa kweCathepsin-L inhibitors.
Cetylpyridinium chloride (CPC)
Quaternary ammonium makomisheni ane inozivikanwa coronavirus chiitiko
| Molecule | Antiviral basa | Mechanism | FDA yakabvumidzwa | Uses |
| Ammonium Chloride | Murine coronavirus, hepatitis C, | Lysosomotropic | Ehe | Kushandiswa kwakasiyana kunosanganisira metabolic acidosis. |
| Cetylpyridinium chloride | Furuwenza, hepatitis B, poliovirus 1 | Targets capsid uye iri lysosomotropic | Hongu, GRAS | Antiseptic, mouthwash, kukosora lozenges, zvigadzirwa zvekuchengeta munhu, zvigetsi zvekuchenesa nezvimwe. |
Nguva yekutumira: Aug-03-2021