Olivetol, inozivikanwawo se5-pentylresorcinol, ikomisheni inongoitika yakagamuchira kutariswa kwakanyanya mumakore achangopfuura nekuda kwekushandisa kwayo mishonga nemaindasitiri.Iyo inotangira mamorekuru kune biosynthesis yeakasiyana makomisheni, kusanganisira cannabinoids anowanikwa zvakanyanya mumuti we cannabis.Kunzwisisa iyo biosynthesis yeolivetolkwakakosha kuona kugona kwayo uye kuongorora mashandisirwo ayo akasiyana.
Iyo biosynthesis yeOlivetolinotanga nekugadzirisa kwemamorekuru maviri emalonyl-CoA, anobva kuacetyl-CoA, kuburikidza nekuita kwe enzyme inonzi polyketide synthase.Iyi condensation reaction inotungamira mukuumbwa kwemusanganiswa wepakati unonzi geranyl pyrophosphate, inova inowanzoitika mu biosynthesis yezvakasiyana zvigadzirwa zvakasikwa, kusanganisira terpenes.
Geranyl pyrophosphate inozoshandurwa kuita olive acid kuburikidza nenhevedzano yemaitiro enzymatic.Danho rekutanga rinosanganisira kuendesa boka reisoprenyl kubva kugeranyl pyrophosphate kuenda kune hexanoyl-CoA molecule, kugadzira komisheni inonzi hexanoyl-CoA olive acid cyclase.Iyi cyclization reaction inogadziriswa ne enzyme inonzi hexanoyl-CoA: olivelate cyclase.
Nhanho inotevera mukatiolivetolbiosynthesis inosanganisira kushandurwa kwehexanoyl-CoA olivetate cyclase kuita fomu inoshanda inonzi tetraketide yepakati.Izvi zvinowanikwa kuburikidza nekutevedzana kwemaitiro enzymatic anokonzerwa nema enzymes akadai chalcone synthase, stilbene synthase, uye resveratrol synthase.Aya maitiro anotungamira mukuumbwa kwe tetraketide yepakati, iyo inozoshandurwa kuita olivetol nekuita kwe polyketide reductase.
Kamweolivetolinogadzirwa, inogona kuchinjwazve kuva mishonga yakasiyana-siyana, kusanganisira cannabinoids, kuburikidza nekuita kwema enzymes akadai cannabidiolic acid synthase uye delta-9-tetrahydrocannabinolic acid synthase.Aya ma enzymes anokonzera condensation yeolivetolne geranyl pyrophosphate kana mamwe mamorekuru epamberi kuti aumbe akasiyana cannabinoids.
Pamusoro pebasa rayo mu cannabinoid biosynthesis,olivetolyakawanikwa iine zvinogona antifungal uye antioxidant properties.Zvidzidzo zvakaratidza izvozvoolivetolinogona kutadzisa kukura kwemhando dzakasiyana-siyana dzefungal pathogens, zvichiita kuti ive mumiriri anovimbisa wekugadzirwa kwemishonga inorwisa fungal.Uyezve,olivetolyakaratidzwa kuve ine simba rekutsvaira basa rinopesana nemahara radicals, ari mamorekuru anoshanda zvakanyanya anogona kukonzera kukanganisa kumaseru nematishu.Iyi antioxidant pfuma yeolivetolinoratidza kushandiswa kwayo kunogona kuita mukugadzira mishonga yekurapa kwezvirwere zvine chekuita neoxidative kusagadzikana.
Muchidimbu, iyo biosynthesis yeolivetolinosanganisira kudzokororwa kwemalonyl-CoA molecules, inoteverwa nenhevedzano yemaitiro enzymatic, zvichikonzera kuumbwa kweolivetol.Mushonga uyu unoshanda seyekutanga mamorekuru mune biosynthesis ye cannabinoids pamwe nezvimwe zvigadzirwa zvechisikigo.Kunzwisisa iyo biosynthetic nzira yeOlivetolyakakosha pakuvandudza mashandisirwo ayo angangoita muminda yemishonga nemaindasitiri.Kumwe kutsvagisa mune biosynthesis yeolivetoluye mabviro ayo anogona kutungamirira mukuwanikwa kwemishonga mitsva yemishonga uye rubatsiro mukugadzirwa kwemishonga mitsva.
Nguva yekutumira: Nov-13-2023